The study showed that the modified ketogenic diet affects intestinal microbiome and metabolic processes associated with Alzheimer's biomarkers. Dr. Harium Yadav, associate professor of molecular medicine at Wake Forest College of Medicine, said: "We have attracted our attention the relationship between gastrointestinal bacteria and diseases related to neurodegenerative diseases. "The association of gastrointestinal microbiome changes with Alzheimer's disease, and adherence to the ketogenic diet can affect these bacteria in ways that reduce dementia, a symptom of Alzheimer's disease."
The randomized study included 17 elderly people, including 11 people with cognitive impairment, and the other six had a normal cognitive sense. Randomly, participants were assigned to either an average ketogenic diet or a low-carbohydrate low-fat diet for six weeks, after a six-week period until they could change to another diet.
The researchers measured gut microbiome, short-chain fecal fatty acids, and signs of Alzheimer's disease – including amyloid and tau proteins – in cerebrospinal fluid before and after each diet period.
"Our findings are important information on which future clinical studies can be based," the researchers concluded.
A low-carbohydrate and high-fat diet can promote fat loss and can help control certain conditions such as type 2 diabetes and cognitive decline.